Human Sera
Cayman Chemical TrIclabendazole 100mg
A benzimidazole anthelmintic; eliminates both immature and adult flukes in a sheep model of F. hepatica infection at 10 mg/kg; protects against glucose- or α-synuclein-induced apoptosis in S. cerevisiae at 5 µM
Cayman Chemical 1PalmItoyl2Oleoylsnglyce 100mg
A phospholipid; a major component of E. coli bilayers; vesicles composed of 1,2,-POPE can be disrupted by polycationic antimicrobials; has been used in combination with other lipids in the formation of LNPs for spleen- and liver-specific targeting in mice
Cayman Chemical TesofensIn 100mg
A triple monoamine reuptake inhibitor; reduces body weight and food intake in a rat model of high-fat diet-induced obesity at 2 mg/kg
Cayman Chemical 4NItrophenyl DCelobIosId 100mg
An enzyme substrate; has been used to characterize function of endoglucanase 1 from T. harzianum, β-glucosidase from T. xylanolyticum, and GH3 aryl β-glucosidases from A. oryzae
Cayman Chemical IsobutyrylLcarnItInchLR 50mg
An acylcarnitine; elevated levels are associated with isobutyryl-CoA dehydrogenase deficiency
Cayman Chemical DIflubenzuron 100mg
An insecticide; inhibits chitin synthesis (IC50 = 0.611 nM); inhibits chitin synthetase at the egg and larval stages; genotoxic and mutagenic in mice at doses of 0.3, 1, and 3 mg/kg
Cayman Chemical LIpId III-45 50mg
An ionizable cationic lipid; has been used in the generation of LNPs for the delivery of mRNA in vivo; LNPs containing lipid III-45 and encapsulating a luciferase mRNA reporter accumulate in liver and adipose tissue in mice; LNPs containing lipid III-45 have been used to deliver an mRNA sequence encoding an antibody targeting claudin-18.2 to mice and reduce tumor volume in an MDA-MB-231 mouse xenograft model
Cayman Chemical DorIpenmhydrate 100mg
A broad-spectrum antibiotic; is active against Gram-negative and Gram-positive bacteria, including S. aureus, S. pneumoniae, E. coli, and K. pneumoniae (MICs = 0.03-0.06, 0.016-0.06, P. aeruginosa respiratory tract infection at 100 mg/kg per day
Cayman Chemical PropIverInhydrochlorIde 50mg
A muscarinic acetylcholine receptor antagonist; binds to M1 and M2 mAChRs in rat bladder and submaxillary gland, respectively (Kis = 0.3 and 0.19 µM, respectively); inhibits carbachol-induced contraction of bladder strips isolated from patients with normal bladder activity and detrusor overactivity associated with benign prostatic hyperplasia (pA2s = 7.7 and 7.6, respectively)
Cayman Chemical MethsuxImIde 100mg
An anticonvulsant; inhibits CYP2C19-mediated metabolism of chlorproguanil and proguanil at 100 µM; protects against leptazol-induced convulsions in rats when administered at a dose of 100 mg/kg
Cayman Chemical FlavoxatehydrochlorIde 50mg
An inhibitor of L-type calcium channels and an antimuscarinic agent; induces relaxation of potassium-precontracted isolated human urinary bladder detrusor muscle (IC50 = 2 µM) and reduces carbachol- or calcium-induced contractions in isolated rat detrusor strips; inhibits reflex micturition in decerebrated cats when microinjected into the oral pontine reticular nucleus at 0.68 UG/animal
Cayman Chemical 4 2 2 3TrImthylcycloPNtyl 50mg
An orthosteric, insurmountable antagonist of the human bitter taste receptors hTAS2R31 and hTAS2R43; prevents the activation of hTAS2R31 by saccharin and acesulfame K in cells (IC50s = 7.9 and 2.4 µM, respectively)